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Research comparing the two has shown that copper chelation generally enhances the biological activity of the peptide, particularly for collagen-stimulating and angiogenic effects

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A 2008 follow-up in Inflammation Research characterized early functional recovery (days 14 post-transection) using the Achilles Functional Index, myeloperoxidase activity, and vascular index, and reported anti-inflammatory effects together with increased new vessel formation (Krivic et al., 2008)

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